THERAPEUTIC STUDIES IN HYPERTHYROIDISM: METHIMAZOLE

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Abstract
The initial dosage of methimazole (1-methyl-2-mercaptoimidazole) was usually 30 mg. daily in divided doses. 24 patients continued to the end of the studies. Of these, 21 had good therapeutic results. Of the 3 who failed, 2 had severe hematologic reactions and the 3d gave unsatisfactory response. The avg. patient became euthyroid in 2-4 weeks. Of the 2 serious reactions, 1 developed leukopenia and fever, the other had thrombocytopenic purpura.

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