Effect of dopamine on pancreatic secretion in the dog

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Abstract
1 Effects of l-dopa and dopamine on the secretion of pancreatic juice were investigated in preparations of the isolated blood-perfused canine pancreas. 2 Dopamine (1–10 μg) given intra-arterially caused a profuse flow of juice. 3 The secretory activity of dopamine (3 μg) was approximately equal to that of secretin (0·1 unit). 4 l-Dopa (10–100 μg) given by a single intra-arterial injection was ineffective, but infusion at 100 μg/min for 10 min caused a marked increase of secretion after a delay of a few minutes. 5 Intravenous administration of either l-dopa (3 mg/kg) or dopamine (10–100 μg/kg) elicited a marked increase of pancreatic secretion, but was definitely less effective than intra-arterial injection. 6 Dopamine-induced secretion was not modified by atropine, phentolamine, propranolol, guanethidine or tetrodotoxin. 7 It is concluded that dopamine acts directly on the exocrine cells in the pancreas.

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