PERSISTENCE OF IMMUNOGENICITY OF 2 COMPLEX ANTIGENS RETAINED IN VIVO

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  • 1 January 1968
    • journal article
    • research article
    • Vol. 14  (4) , 491-+
Abstract
The persistence of immunogenicity of lipo-polysaccharide antigens of Escherichia coli and of sheep red blood cells [SRBC] in the mouse was studied by a transfer system. Immunized mice were lethally irradiated and re-populated with non-immune syngeneic lymphoid and bone marrow cells at different times after immunization. Persistence of immunogenicity in the irradiated hosts was revealed as the induction of a primary immune response in the transferred cells. In this system SRBC persisted in an immunogenic form for 14 days whereas the bacterial antigens remained immunogenic for at least 45 days.