Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients
- 1 January 1983
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 12 (suppl A) , 93-99
- https://doi.org/10.1093/jac/12.suppl_a.93
Abstract
A randomized study of gentamicin plus cefotaxime versus ceftazidime alone was performed in 87 patients, with a neutrophil count of < 1000/mm 3 at the start of the treatment. The overall cure rate for the ceftazidime group was 71% and for the gentamicin plus cefotaxime 47%. This difference was shown to be statistically significant at a level of P < 0.05. The cure rates for the microbiologically proven infections were 90 and 63% respectively. Serious adverse effects, causing preliminary withdrawal of therapy, have not been observed.Keywords
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