Specific Inhibition of Viral Ribonucleic Acid Replication by Gliotoxin
- 26 January 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3813) , 431-432
- https://doi.org/10.1126/science.159.3813.431
Abstract
Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.This publication has 12 references indexed in Scilit:
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