A PROSPECTIVE TRIAL OF 5-FU AND BCNU IN THE TREATMENT OF ADVANCED GASTRIC CANCER

Abstract
The efficacy of a combination of 5-FU [5-fluorouracil] and BCNU [1-bis-2-chloroethyl-1-nitrosourea] in the treatment of advanced gastric cancer was studied. Patients whose cancer was recurrent following surgery or in whom surgery was deemed inappropriate were entered in the study and given the 2-drug combination at 6 wk intervals until death or clear progression of disease occurred. Of twenty-eight patients had unequivocal regression of their disease. The early optimism for this form of therapy in advanced gastric cancer is not supported by this study.