Dose‐dependent effects of oral acyclovir in the incubation period of varicella
- 1 December 1996
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 85 (12) , 1418-1421
- https://doi.org/10.1111/j.1651-2227.1996.tb13945.x
Abstract
Dose of acyclovir (ACV) and clinical features of varicella were evaluated in 65 household contacts (0.8‐9 y) who received oral ACV (5‐80 mg/kg daily in four divided doses) during the latter half of the incubation period of varicella. The severity of the disease was compared with that of 23 children who did not receive ACV. Infection was confirmed by a fluorescent antibody to membrane antigen assay. The antibody titers and the rate of apparent infection increased as the dose of ACV administered decreased. The number of skin lesions in patients who received ACV was significantly reduced when compared to the control group. These data suggest dose‐dependence of ACV for modification of varicella during secondary viremia in the incubation of the disease.Keywords
This publication has 19 references indexed in Scilit:
- ACYCLOVIR PROPHYLAXIS OF VARICELLA AFTER HIOUSEHOLD EXPOSUREThe Pediatric Infectious Disease Journal, 1995
- THE PEDIATRIC RESIDENT SUSCEPTIBLE TO VARICELLAThe Pediatric Infectious Disease Journal, 1994
- Effect of oral acyclovir against primary and secondary viraemia in incubation period of varicella.Archives of Disease in Childhood, 1993
- Varicella‐zoster virus replication site in internal organs of an otherwise healthy child with varicella and sudden deathPediatrics International, 1993
- Acyclovir treatment of varicella in otherwise healthy adolescentsThe Journal of Pediatrics, 1992
- Treatment of adult chickenpox with oral acyclovirArchives of internal medicine (1960), 1990
- Acyclovir treatment of varicella in otherwise healthy childrenThe Journal of Pediatrics, 1990