Three-dimensional structure of the free radical protein of ribonucleotide reductase
- 1 June 1990
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 345 (6276) , 593-598
- https://doi.org/10.1038/345593a0
Abstract
The enzyme ribonucleotide reductase furnishes precursors for the DNA synthesis of all living cells. One of its constituents, the free radical protein, has an unusual alpha-helical structure. There are two iron centres that are about 25 A apart in the dimeric molecule. Tyrosine 122, which harbours the stable free radical necessary for the activity of ribonucleotide reductase, is buried inside the protein and is located 5 A from the closest iron atom.Keywords
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