Ranitidine kinetics in normal subjects

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Abstract
A 1-mg/kg i.v. bolus injection and a 150-mg (1 tablet) oral dose of ranitidine [an antiulcer drug] were given to 7 normal subjects. At least 1 wk separated the 2 doses. Ranitidine disappeared from plasma with a half-life [t1/2] of .apprx. 2.5 h. Half of the oral dose was effectively absorbed and half of the absorbed amount was found unchanged in urine. Total body clearance was 10.1 ml/min per kg. Urinary clearance was the same after oral and i.v. doses (6.4 and 6.9 ml/min per kg, P > 0.10). I.v. ranitidine kinetics included 3 phases, with a central distribution volume of 0.2 l/kg and a total distribution volume of 1.2 l/kg. Absorption kinetics were apparently zero order: of the 150-mg dose, 75 mg was absorbed during 5 h at a constant rate of 15 mg/h.

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