CEFTIOFUR SODIUM, A BROAD-SPECTRUM CEPHALOSPORIN - EVALUATION INVITRO AND INVIVO IN MICE

  • 1 July 1987
    • journal article
    • research article
    • Vol. 48  (7) , 1050-1053
Abstract
Ceftiofur sodium, a broad-spectrum .beta.-lactamase-resistant cephalosporin, was evaluated in vitro and in vivo in mice. Ceftiofur is the sodium salt of (6R,7R)-7{[2-amino-4-thiazolyl)-Z-(methoxyimino)acetyl]amino}-3-{[(2-furanylcarbonyl)thio]methyl}-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylate. Minimal inhibitory concentration values were obtained with 264 strains representing 9 genera and 17 species of bacterial pathogens from cattle, swine, sheep, horses, poultry, dogs, cats, and human beings. Ceftiofur was more active than was ampicillin against all strains tested including .beta.-lactamase-producing organisms. In mice with sytemic infections, ceftiofur was more active than or equivalent to ampicillin, cephalothin, cefamandole, cloxacillin, cefoperazone, or pirlimycin. These protection tests included infections with Escherichia coli, Haemophilus pleuropneumoniae, H. somnus, Pasteurella haemolytica, P. multocida, Salmonella typhimurium, or Staphylococcus aureus. In infant mice with E. coli-induced lethal diarrhea and in mice with S. aureus and E. coli-induced mastitis ceftiofur was comparable or more active than was ampicillin.