RECOGNITION BY HUMAN AND RABBIT SERA OF COMMON ANTIGENS TO LEUKEMIA BLAST CELLS, PERIPHERAL-BLOOD B-LYMPHOCYTES, AND MONOCYTES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (10) , 3656-3662
Abstract
Human serum (obtained from a multiparous and multiple transfused patient with chronic myelogenous leukemia) and rabbit antiserum (obtained by immunization with papain extracts from a B[bone marrow-derived]-lymphoblastoid cell line) showed reactivity against antigenic specificities (different from HLA) expressed on peripheral blood B lymphocytes, unmarked lymphocytes and monocytes. These antigenic determinants were expressed on myeloblasts and lymphoblasts from patients with acute leukemia (during the active phase of their disease) and B lymphoblastoid cell lines and lymphocytes from patients with chronic lymphocytic leukemia. Purified peripheral blood T[thymus-derived]-lymphocytes, mitogen (phytohemagglutinin) activated T lymphocytes and lymphoblasts (with T cell characteristics) obtained from patients with acute lymphoblastic leukemia or established lymphoblastoid cell lines lacked these antigenic specifities. Absorption experiments indicate that the antigen(s) detected on normal mononuclear cell populations, leukemia cells and B lymphoblastoid cell lines were identical or highly cross-reactive.

This publication has 0 references indexed in Scilit: