Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

This publication has 85 references indexed in Scilit:

• Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
  Nature Neuroscience, 2010
• Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
  Published by Elsevier ,2010
• Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
  Cell, 2009
• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
  Nature, 2009
• Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory
  Nature Neuroscience, 2008
• Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
  Nature Medicine, 2008
• Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
  Proceedings of the National Academy of Sciences, 2008
• Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
  Nature Neuroscience, 2004
• Influence of TOR kinase on lifespan in C. elegans
  Nature, 2003
• mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
  Cell, 2002