DNA precursor metabolism and genomic stability
Top Cited Papers
- 1 July 2006
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 20 (9) , 1300-1314
- https://doi.org/10.1096/fj.06-5730rev
Abstract
Intracellular concentrations of the four deoxyribonucleoside triphosphates (dNTPs) are closely regulated, and imbalances in the four dNTP pools have genotoxic consequences. Replication errors leading to mutations can occur, for example, if one dNTP in excess drives formation of a non-Watson-Crick base pair or if it forces replicative DNA chain elongation past a mismatch before DNA polymerase can correct the error by 3′ exonuclease proofreading. This review focuses on developments since 1994, when the field was last reviewed comprehensively. Emphasis is placed on the following topics: 1) novel aspects of dNTP pool regulation, 2) dNTP pool asymmetries as mutagenic determinants, 3) dNTP metabolism and hypermutagenesis of retroviral genomes, 4) dNTP metabolism and mutagenesis in the mitochondrial genome, 5) chemical modification of nucleotides as a premutagenic event, 6) relationships between dNTP metabolism, genome stability, aging, and cancer.—Mathews, C. K. DNA precursor metabolism and genomic stability.Keywords
Funding Information
- National Science Foundation (MCB 9906576)
- Army Research Office (LS-45039)
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