Pharmacokinetics of Lonidamine after Oral Administration in Cancer Patients

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Abstract
The pharmacokinetics of lonidamine has been studied in cancer patients after single and chronic oral administrations. After single administration the plasma kinetics are highly variable, while the dose eliminated in the urine is over 70% in all subjects. This suggests an active but interindividually variable first-pass effect. After repeated administrations, both the residual plasma concentration before administration () and that obtained after drug intake () have been studied. The values range from 4.5 to 25 µg/ml and values from 0.4 to 7 µg/ml. In patients where a therapeutic response was noted, a mean value of 2.98 Hg/ml for C^?n was measured. In patients unresponsive to drug therapy the mean was 1.5 µg/ml.

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