ENHANCED RENAL TUBULAR CALCIUM REABSORPTION INDEPENDENT OF PARATHORMONE ACTIVITY, IN CHILDREN ON LONG TERM ANTICONVULSANT THERAPY

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Abstract
A significant reduction in the urinary Ca-creatinine ratio was found in 34 ambulatory epileptic children on long term anticonvulsant therapy, studied during wintertime. No significant difference in the urinary excretion of cyclic AMP, phosphate or amino acids was observed when the study-group was compared to an age-matched control group. Serum Ca and phosphate values were normal, but a significant increment in alkaline phosphatase was noted. Since there was no evidence of hyperactivity of the parathormone, it is suggested that the enhanced renal tubular Ca reabsorption in children on long term anticonvulsant therapy is a nonparathormone-mediated phenomenon, possibly compensating for reduced Ca absorption in the gastrointestinal tract.