Pharmacokinetics of intravenous theophylline

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Abstract
Plasma theophylline concentrations were measured after single intravenous infusions of aminophylline to asthmatic patients and normal volunteers. Using two‐compartment kinetic analysis, no basic differences in drug disposition were found. For the 16 subiects studied the overall mean plasma clearance rate was 0.0719 I per kilogram per hour, and overall mean beta or slow disposition constant was 0.159 hr−1, corresponding to a plasma half‐time of 4.36 hr. This information should be useful in determining precise dosage requirements for theophylline in clinical situations.

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