Two-Sample Hemodialysis Urea Kinetic Modeling: Validation of the Method

1 January 1995

journal article
research article
Published by S. Karger AG in Nephron

Vol. 69 (1) , 49-53
https://doi.org/10.1159/000188359

Abstract

Urea kinetic modeling (UKM) by a two-sample method (UKM₂) was compared with the classical three-sample method (UKM₃) and direct quantification. Assuming the patient to be in a weekly steady state and using an approximate treatment schedule, UKM2 can compute urea generation rate (G), distribution volume (V), Kt/V, and normalized protein catabolic rate (NPCR). Twenty-three stable patients were examined. The results obtained by UKM₂ and UKM₃ differed little (G -4.2%, V -1.0%, Kt/V 0.9%, NPCR -2.7%), and the correlations between them were high (r > 0.96). The differences between UKM₂ and direct quantification were greater, but also highly correlated. G determined midweekly by UKM₂ was highly correlated with G found directly from 1-week collection of dialysate and urine (r = 0.96). Repeating analysis over a 5-week period, the results obtained by UKM₂ varied no more than those obtained by UKM₃ (around 8% for all four kinetic variables). In conclusion, UKM₂ produces reliable results requiring less data to be entered than using UKM₃.

Keywords

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