Crystalline and Macrocrystalline Nitrofurantoin in the Treatment of Urinary-Tract Infection

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Abstract
SINCE the first reports1 of the successful use of nitrofurantoin in the treatment of urinary infection, this drug has been widely accepted as a reliable and effective antimicrobial in the treatment2 and prophylaxis3 , 4 of urinary-tract infections in patients with normal renal function.A major advantage of the drug for prophylaxis is that, because the blood levels are negligible, the intestinal and normal introital flora are not altered.3 Moreover, most bacteria do not become resistant.5 The reported rate of adverse reactions2 , 6 7 8 varies between 3.5 and 40 per cent, and these reports2 , 6 , 7 may represent only a small fraction of the adverse reactions . . .