Persistent Chromosomal Aberrations Following Radioiodine Therapy for Thyrotoxicosis

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Abstract
PRESENT evidence indicates that human chromosomes are at risk whenever exposed to ionizing radiation. Chromosomal aberrations have been demonstrated after accidental,1 2 3 therapeutic4 , 5 and diagnostic6 7 8 exposures. Initially, such defects were noted after high-level radiation exposure. Incriminated early were such forms of exposure as x-ray therapy, for ankylosing spondylitis,4 , 5 prodigious doses of radioiodine (131I) for carcinoma of the thyroid gland9 , 10 and accidental gamma and neutron irradiation.1 In some cases these aberrations have been observed twenty years after exposure.5 More recently, low-level radiation exposure in the form of certain diagnostic x-ray procedures has been demonstrated to cause less severe but significant chromosomal . . .