How and why criteria defining moderators and mediators differ between the Baron & Kenny and MacArthur approaches.

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Abstract
In recognition of the increasingly important role of moderators and mediators in clinical research, clear definitions are sought of the two terms to avoid inconsistent, ambiguous, and possibly misleading results across clinical research studies. The criteria used to define moderators and mediators proposed by the Baron & Kenny approach, which have been long used in social/behavioral research, are directly compared to the criteria proposed by the recent MacArthur approach, which modified the Baron & Kenny criteria. After clarifying the differences in criteria between approaches, the rationale for the modifications is clarified and the implications for the design and interpretation of future studies considered. Researchers may find modifications introduced in the MacArthur approach more appropriate to their research objectives, particularly if their research might have a direct influence on decision making.
Funding Information
  • MacArthur Network on Development and Psychopathology
  • National Institute on Aging (AG17824)
  • US Department of Veterans Affairs
  • National Heart, Lung and Blood Institute (R29 HL60154)
  • American Heart Association
  • National Institute of Mental Health (P50 MH069315)
  • University of Wisconsin-Madison