Chemical and Chemotherapeutical Studies on the Furan Derivatives. XXXI

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Abstract
2-Amino-5-[2-(5-nitro-2-furyl) vinyl]-1, 3, 4-thiadiazole (I) was prepared by the oxidation of nitrofurylacrolein thiosemicarbazone. Eight kinds of similar-type compounds were prepared, and their antibacterial action and therapeutic effect against mice infected with Streptococcus haemolyticus were examined. I had a great effect and its effect was compared with that of sulfamethylthiadiazole (Urocydal), which is known as the urethral infection therapeutic. It was thereby learned that the nitrofuran ring had chemotherapeutic effect even in vivo.

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