LOCALIZATION OF ALLOGENEIC LYMPHOID-CELLS IN RELATION TO ANTIBODY-MEDIATED IMMUNOSUPPRESSION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 36  (3) , 533-538
Abstract
Carbon blockade of mice did not affect cytotoxic antibody production after immunization with allogeneic cells, nor did it affect the immunosuppressive activity of alloantibody. Though it inhibited the alloantibody-mediated increase in hepatic localization of allogeneic lymphoid cells it had no effect on the normal hepatic localization of allogenic lymphoid cells. Alloantibody administered before allogeneic cells or 6 h after was equally immunosuppressive, but anti-lymphocyte antiboyd only had potent immunosuppressive activity when given just before the antigenic cells. An afferent mechanism of suppression of the humoral antibody response can apparently be exerted by anti-lymphocyte serum, and alloantibody may also act by this method when given before the antigen. As alloantibody is also highly potent when given after the antigen when an afferent mechanism is unlikely to occur, studies on the specificity of immunosuppression, particularly the likely requirement for antibody to I region determinants, would best be conducted by giving the antibody after the antigen, thereby avoiding any possible afferent inhibitory activity.