Serotonin Antagonist Increases Longevity in Mice With Hereditary Muscular Dystrophy.

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Abstract
Survival time was increased over 90% in mice with hereditary muscular dystrophy treated orally with a serotonin [5-hy-droxytryptamine] antagonist, methysergide bimaleate. There was a concurrent increase in body weight in the treated animals. Short term treatment for 3 weeks with the drug given intraperitoneally significantly enlarged the ovaries of dystrophic mice, but had no effect on body weight or other endocrine organ weights of normal mice.

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