Double‐blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome

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Abstract
Aim: To study the effect of prokinetic treatment with cisapride in patients with constipation‐predominant irritable bowel syndrome.Patients and methods: Ninety‐six patients were randomly assigned to treatment with either cisapride 5 mg three times daily or placebo three times daily for a period of 12 weeks. The dosage could be doubled after 4 weeks. Presence of the target symptoms abdominal pain, constipation and abdominal bloating was an obligatory criterion for inclusion in the study.Results: After 12 weeks of treatment, 31%, 56% and 27% of the cisapride treated patients were found to be without the three target symptoms (PPPP0.05).Conclusions: These results indicate that cisapride is not superior to placebo in the treatment of constipation and abdominal discomfort as components of irritable bowel syndrome. It may, hovever, be of use in improving the difficulty of stool passage.

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