DAUNORUBICIN, DAUNORUBICINOL AND DNA PLASMA KINETICS AFTER IV ADMINISTRATION OF DAUNORUBICIN-DNA COMPLEX IN RABBIT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 29  (5) , 164-167
Abstract
The pharmacokinetics of daunorubicin and daunorubin-DNA complex were studied in the rabbit after i.v. bolus injection and a 4 h infusion period. The plasma levels of daunorubicin and daunorubicinol were measured by high-pressure liquid chromatography and the DNA plasma levels by means of 125I labeled DNA. The results demonstrated a slower distribution of the complex, but the more rapid decrease in the plasma levels of daunorubicin than that of DNA suggested that this complex essentially constitutes a daunorubicin circulating pool from which the drug diffuses more slowly than after the administration of uncomplexed daunorubicin.