Growth of Measles Virus in the Lymphoid Tissues of Monkeys

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Abstract
The lymphoid tissues of monkeys infected with wild measles virus were examined by light microscopy and the fluorescent antibody technique. There was a good correlation between distribution of viral antigen and giant cells, most of which were of the reticular type. A large amount of viral antigen was always detected in giant cells, which suggested that these cells might be formed as a result of growth of measles virus in situ. Major growth sites of measles virus were found to be as the spleen, lymph nodes, and tonsils. It also appeared that the thymus and cecum might be involved to a lesser extent than the other lymphoid organs. Evidence of growth of virus in the bone marrow was not obtained. The possibility that the reticular cells are a main target of growth of measles virus was considered.

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