State-of-the-Art Review : Nitric Oxide and Restenosis
- 1 January 1996
- journal article
- review article
- Published by SAGE Publications in Clinical and Applied Thrombosis/hemostasis
- Vol. 2 (1) , 7-10
- https://doi.org/10.1177/107602969600200102
Abstract
Restenosis after balloon angioplasty of vascu lar lesions in patients with atherothrombotic disease re mains an important complication of the procedure. At tempts to limit restenosis have been generally unsuccess ful. The endothelial cell normally produces several factors that limit the molecular and cellular events under lying the restenotic response. Chief among these is en dothelium-derived relaxing factor/nitric oxide. This sim ple molecule inhibits platelet activation, secretion, adhe sion, and aggregation; relaxes the underlying vascular smooth muscle cell; impairs leukocyte adhesion to the vessel wall; and limits vascular smooth muscle cell pro liferation. The mechanistic bases for these observations are presented in this overview, and experimental in vivo data that support the benefits of nitric oxide and nitric oxide donors in the prevention of restenosis are also re viewed.Keywords
This publication has 16 references indexed in Scilit:
- Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia.Journal of Clinical Investigation, 1993
- L-Arginine Inhibits Balloon Catheter-Induced Intimal HyperplasiaBiochemical and Biophysical Research Communications, 1993
- SIN-1 reduces platelet adhesion and platelet thrombus formation in a porcine model of balloon angioplasty.Circulation, 1993
- The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disordersJournal of the American College of Cardiology, 1991
- Nitric oxide: an endogenous modulator of leukocyte adhesion.Proceedings of the National Academy of Sciences, 1991
- Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.Circulation, 1991
- Restenosis after percutaneous transluminal coronary angioplasty: Pathologic observations in 20 patientsJournal of the American College of Cardiology, 1991
- Persistent dysfunction of regenerated endothelium after balloon angioplasty of rabbit iliac artery.Circulation, 1990
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.Journal of Clinical Investigation, 1989
- The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineNature, 1980