Infertility in human males with autosomal translocations: meiotic study of a 14;22 Robertsonian translocation
- 1 December 1990
- journal article
- case report
- Published by Springer Nature in Human Genetics
- Vol. 86 (2) , 162-166
- https://doi.org/10.1007/bf00197698
Abstract
Pachytene analysis was undertaken in a male patient heterozygous for a 14q22q Robertsonian translocation. The relatively low rate of XY autosome association led us to examine the relationships existing between the chromosomes involved in the translocation, the rate of XY-autosome association and the degree of spermatogenic failure. Cytogenetic investigations in infertile men and the results of the meiotic studies suggest a direct correlation between the frequency of XY-autosome association at pachytene and the degree of spermatogenic failure. Whether associations arise as a consequence or cause of germ cell failure is still not certain.Keywords
This publication has 18 references indexed in Scilit:
- Pachytene pairing in relation to sperm and oocyte numbers in a male-fertile reciprocal translocation in the mouseCytogenetic and Genome Research, 1988
- Electron microscopic investigations of synaptonemal complexes in an infertile human male carrier of a pericentric inversion inv(1)(p32q42)Human Genetics, 1987
- Two different XY-quadrivalent associations and impairment of fertility in menCytogenetic and Genome Research, 1986
- Loop formation and synaptic adjustment in a human male heterozygous for two pericentric inversionsChromosoma, 1986
- A human 9;20 reciprocal translocation associated with male infertility analyzed at prophase and metaphase I of meiosisCytogenetic and Genome Research, 1986
- Meiotic association between the XY chromosomes and the autosomal quadrivalent of a reciprocal translocation in two infertile men, 46, XY, t(19;22) and 46, XY, t(17;21)Cytogenetic and Genome Research, 1985
- Down's syndrome in the male. Reproductive pathology and meiotic studiesHuman Genetics, 1983
- THE CHROMOSOMAL BASIS OF HUMAN INFERTILITYBritish Medical Bulletin, 1979
- Identification of pachytene bivalents in human male meiosis using G-banding techniqueChromosoma, 1975
- Sex-chromosome pairing and male fertilityCytogenetic and Genome Research, 1974