Gamma-A Deficiency and Hypochromic Anemia Due to Defective Iron Mobilization

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Abstract
AN unusual defect in iron metabolism was demonstrated in a patient, who showed the clinical and histologic features of idiopathic pulmonary hemosiderosis.1 Iron kinetic studies indicated that iron was lost into a site where it could not be reutilized for hematopoiesis, causing hypochromic anemia and reticulocytosis. "Iron trapping" in the lung,2 presumably because of fibrosis and lymphatic obstruction,3 , 4 is characteristic of idiopathic pulmonary hemosiderosis. However, the findings presented below suggest that the defect in iron mobilization may be a generalized dysfunction located in the macrophage system, both in this case and in other cases of this condition. It will be . . .
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