Spontaneous Nε-methylation and Nε-formylation reactions between l-lysine and formaldehyde inhibited by l-ascorbic acid

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Abstract
For the inhibition of spontaneous N.epsilon.-methylation and N.epsilon.-formylation reactions between L-lysine and formaldehyde, L-ascorbic acid proved to be most suitable. The inhibition was not complete unless the molar concentration of ascorbic acid exceeded that of formaldehyde. TLC, potentiometric titration, NMR, spectroscopy and radiometric analysis were applied in the study of the inhibition process. Formaldehyde was reduced by L-ascorbic acid to ethylene glycol.