Early Morphological Changes of the Corneal Epithelium after Burning with Hydrochloric Acid

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Abstract
The morphological changes in the corneal epithelium after burning with HCl were examined using a scanning electron microscope. A drop of HCl of differing concentrations (1-0.000001 N HCl) was applied under standarized conditions to normal rabbit eyes for a reaction period of 5 or 30 min. The changes in the cell surface, which are dependent on the concentration of the acid, include a loss of microvilli and microplicae, outlining of the cell nucleus, disruption of the intercellular spaces, cell desquamation and even the most severe damage to the cell membrane and cytoplasm of the corneal epithelial cells.

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