Small Virus-like Particles in Honey Bees associated with Chronic Paralysis Virus and with a Previously Undescribed Disease

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Abstract
Summary Chronic bee-paralysis virus associate (CPVA) and cloudy wing particle (CWP) are about 17 nm in diam. contain RNA, have single polypeptide species and have indistinguishable buoyant densities in CsCl of about 1.38 g/ml; but they are serologically unrelated, have proteins of different mol. wt. and have significantly different sedimentation coefficients of 41S and 49S respectively. CPVA is significantly and possibly specifically associated with chronic paralysis virus but multiplies, relative to the paralysis virus, by different amounts in different tissues. CWP multiplies apparently independently.