Enhancement of bone formation in rabbits by recombinant human growth hormone
- 1 January 1993
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 64 (5) , 562-566
- https://doi.org/10.3109/17453679308993693
Abstract
We studied the effect of human recombinant growth hormone on diaphyseal bone in 40 adult rabbits. The diaphyseal periosteum of one femur in each animal was mechanically stimulated by a nylon cerclage band. The bands induced an increase in bone formation, bone mineral content, and maximum torque capacity of the diaphyseal bone at 1 and 2 months. Growth hormone enhanced the anabolic effect of the cerclage bands on bone metabolism, evidenced by a further increase in torsional strength of the femurs.Keywords
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