Deficiency of DNA ligase activity in Fanconi's anemia
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 45 (1) , 25-32
- https://doi.org/10.1007/bf00277570
Abstract
A significant decrease in DNA ligase activity was observed in lymphocytes and fibroblasts of a patient with Fanconi's anemia (FA). This decrease is related to the observed DNA repair deficiency indicated by the delayed closing of repair DNA strands following UV irradiation. Other steps of DNA repair were analyzed in the FA fibroblasts, including endonucleolytic incision of DNA, repair DNA synthesis, and exonucleolytic removal of the photoproducts. No differences were found against control cells. The action of DNA ligase is delayed during replication in the FA cells, as seen by an accumulation of replicative intermediates.Keywords
This publication has 11 references indexed in Scilit:
- Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia.Proceedings of the National Academy of Sciences, 1976
- Formal genetics of Fanconi's anemiaHuman Genetics, 1976
- XERODERMA PIGMENTOSUM: BIOCHEMICAL AND GENETIC CHARACTERISTICSAnnual Review of Genetics, 1975
- Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?Nature, 1975
- DNA ReplicationAnnual Review of Biochemistry, 1975
- Fanconi's anemiaEuropean Journal of Pediatrics, 1975
- Defective DNA repair in Fanconi's anaemiaNature, 1974
- [61] DNA- and RNA-directed synthesis in vitro of phage enzymesPublished by Elsevier ,1974
- Chromosomal peculiarities and ?in vitro? examinations in Fanconi's anaemiaHuman Genetics, 1969
- Spontane Chromosomenaberrationen bei familiärer PanmyelopathieHuman Genetics, 1964