Intermittent Chemotherapy with Trichlorfon (Metrifonate) Reverses Proteinuria, Hematuria, and Leukocyturia in Urinary Schistosomiasis: Results of a Three-Year Field Study

Publisher Website
Google Scholar
Abstract
Trichlorfon (metrifonate) was given intermittently to 37 schoolboys with urinary schistosomiasis living in a hyperendemic area of the Sudan. Patients were followed up for 3 yr. Initially, 10 mg of trichlorfon/kg of body weight was administered; this dosage was repeated 14 days and 16 mo. later. Patients still excreting eggs after 24 mo. received a 4th dose. At mo. 24, 61% and at mo. 36, 56% of the patients had no detectable egg excretion; the others showed severe reduction of egg output. The number of ova excreted was always paralleled by a combined scale of hematuria, leukocyturia, and proteinuria, as assessed by urine analysis reagent strips. Quantitative urine analysis at mo. 36 revealed pathological findings in only 8 individuals. Trichlorfon given three or four times in a dose of 10 mg/kg of body weight spaced over a period of 2 yr was highly effective in reducing parasite load and disease in children living under hyperendemic conditions.

This publication has 10 references indexed in Scilit: