Isolation of Sulfonamides from Fortified Chicken Tissues with Supercritical CO2 and In-Line Adsorption
- 1 July 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 32 (7) , 290-293
- https://doi.org/10.1093/chromsci/32.7.290
Abstract
Improved recoveries and detectability of three sulfonamides from chicken tissues by supercritical fluid extraction (SFE), without modifiers, using an in-line adsorption trap, are reported. Following SFE, the analytes are recovered from neutral alumina with the HPLC mobile phase. Samples are injected directly onto high-performance liquid chromatographic columns without post-extraction cleanup. Mean recoveries of sulfamethazine, sulfadimethoxine, and sulfaquinoxaline from liver, breast tissue, and thigh muscle are 89, 95, and 77%, respectively. The analytes are detectable at less than 100 ppb with a minimum of background interference.Keywords
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