N.M.R. Spectral Studies of Some Quinolone Derivatives. Effect of Substitution on the Degree of Hydrogen Bonding
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Spectroscopy Letters
- Vol. 7 (10) , 503-510
- https://doi.org/10.1080/00387017408067278
Abstract
The chemical shift of the NH protons for a series of monomethyl-, dimethyl- and trimethyl- substituted 2- and 4- quinolones has been studied. Compounds with an 8-methyl substituent exhibit a characteristic upfield shift which is considered to be due to a reduction in hydrogen bonding as a result of steric effects. The application of this effect to the identification of alkyl substituted quinolones and some natural products is discussed.Keywords
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