DNA Breaking Reaction with Catecholamines
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 43 (8) , 1619-1624
- https://doi.org/10.1080/00021369.1979.10863683
Abstract
Breaking activity of catecholamines and their structural analogues on λ DNA were investigated by agarose slab gel electrophoresis. Since λ DNA has a homogenous molecular size, it is a favorable material to detect the activity of DNA breaking reagent. Among the compounds tested, those having enediol group were only active, though their activities remarkably differed owing to their side chains. The profile of the breaking reaction was studied in detail by the use of one of the catecholamines, epinephrine.This publication has 1 reference indexed in Scilit:
- A role for ferrous ion and oxygen in the degradation of DNA by bleomycinBiochemical and Biophysical Research Communications, 1976