Milieux hyperbasiques: préparation de carbanions en α d'amides N,N-disubstitués. Synthèse de β- et γ-hydroxyamides et de γ-butyrolactones
- 15 January 1977
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 55 (2) , 266-273
- https://doi.org/10.1139/v77-041
Abstract
The α anions of N,N-disubstituted carboxamides can be conveniently prepared by treatment with "activated" lithium dialkylamides in HMPT. They react with aldehydes and ketones and lead to β-hydroxyamides; furthermore the ring opening of epoxides affords γ-hydroxyamides which may be cyclized in situ to γ-butyrolactonesKeywords
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