Myoelectric and contractile effects of motilin on dog small intestinein vivo
- 1 October 1986
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 31 (10) , 1062-1072
- https://doi.org/10.1007/bf01300259
Abstract
The effects of the close intraarterial administration of motilin on intestinal myoelectric and contractile activities were examined in 37 dogs. After anesthetization or decerebration, a segment of proximal jejunum was instrumented serosally with electrodes and stain gauges. A mesenteric artery supplying a short length of this segment was cannulated for the injection of motilin and other agents. Motilin (0.03–0.3 μg) caused: (1) a series (1–5 min) of phasic contractions and electrical response activity (ERA) bursts locally; (2) a short (15–60 sec) series of phasic contractions and ERA bursts aborally followed by relaxation; and (3) a series of phasic contractions and ERA bursts whose onset migrated 3.7±1.0 cm orally. The length of orad response increased to 6.6±1.9 cm in the decerebrate dogs (P2α or leucine-enkephalin, cuased similar responses. All motilin responses were mediated by neural pathways consisting of both nicotinic and muscarinic receptors. The similarity of responses and mechanisms of action of the motilin-activated contractile response with the intrinsic mucosal reflex suggested that motilin may mediate this reflex.This publication has 42 references indexed in Scilit:
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