BICYCLIC THIOPHENIC DERIVATIVES AS PLATELET-AGGREGATION INHIBITORS
- 1 June 1986
- journal article
- research article
- Vol. 41 (6) , 478-482
Abstract
The antiplatelet activity of twenty new thiophenic derivatives, grouped in three series, was studied according to the in vitro Born method. The DI50 for the three inducers of platelet aggregation (ADP, adrenaline and collagen) were calculated. The strong antiplatelet activity found in some of the compounds studied, which is even superior to that of the four classic antiplatelet drugs used is worth mentioning. The structure-activity relationships is discussed.This publication has 2 references indexed in Scilit:
- THROMBOXANE SYNTHETASE INHIBITION AS ANTITHROMBOTIC STRATEGYThe Lancet, 1981
- Analogs of propranolol. Synthesis of 3‐alkylamino‐1‐(3‐benzo[b]thienyloxy)‐2‐propanolsJournal of Heterocyclic Chemistry, 1980