Reversal of Anti to Syn Diastereoselectivity in Crotyltitanation Reaction
- 1 November 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (11) , 1239-1240
- https://doi.org/10.1055/s-1997-1002
Abstract
η3-2-Methylcrotyl(tiglyl)titanocene reacts with aldehydes to afford anti homoallylic alcohols when the reaction is carried out in THF, and preferentially syn products when the solvent is HMPA/THF=3:1. This simple control of anti versus syn diastereoselectivity expands considerably the synthetic uses of the crotyltitanation reaction.Keywords
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