The role of the subependymal plate in avian sarcoma virus brain tumor induction:
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 38 (1) , 1-6
- https://doi.org/10.1007/bf00691268
Abstract
F-344 rats were inoculated intracerebrally at 1 and at 133 days of age with the Bratislava-77 strain of avian sarcoma virus. Groups of rats were sequentially sacrificed following inoculation so that early stages of microtumor formation could be evaluated. In neonatally inoculated rats incipient tumors developed in the subependymal region of the lateral ventricles in close juxtaposition to clusters of poorly differentiated germinal cells. Among these animals microtumors were detected as soon as 2 weeks after inoculation; by 4 weeks post-inoculation all rats inoculated at 1 day of age had tumors. In contrast among rats inoculated as adults incipient tumors developed in the cerebral cortex away from the subependymal region but adjacent to the locus of inoculation. Incipient tumors were uncommon in rats inoculated as adults during the first 2 months after inoculation.Keywords
This publication has 16 references indexed in Scilit:
- The Induction of Intracranial Neoplasms by the Inoculation of Avian Sarcoma Virus in Perinatal and Adult RatsJournal of Neuropathology and Experimental Neurology, 1975
- Autoradiographic investigations of glial proliferation in the brain of adult mice. The DNA synthesis phase of neuroglia and endothelial cellsJournal of Comparative Neurology, 1973
- Investigation of glial cells in semithin sections. III. Transformation of subependymal cells into glial cells, as shown by radioautography after 3H‐thymidine injection into the lateral ventricle of the brain of young ratsJournal of Comparative Neurology, 1973
- Tumours of the nervous system induced in rats by the neonatal administration of n‐ethyl‐n‐nitrosoureaThe Journal of Pathology, 1973
- The fine structure of periventricular pleomorphic gliomas induced transplacentally by N-ethyl-N-nitrosourea in BD-IX Rats: With a note on their originJournal of the Neurological Sciences, 1972
- The subependymal layer and neighboring region in the brain of the young ratJournal of Comparative Neurology, 1972
- Brain Tumors Induced in Dogs by the Schmidt-Ruppin Strain of Rous Sarcoma VirusJournal of Neuropathology and Experimental Neurology, 1969
- PATHOLOGY OF EXPERIMENTAL NEUROGENIC TUMORS CHEMICALLY INDUCED DURING PRENATAL AND POSTNATAL LIFEAnnals of the New York Academy of Sciences, 1969
- THE FATE OF THE SUBEPENDYMAL CELL IN THE ADULT RAT BRAIN, WITH A NOTE ON THE ORIGIN OF MICROGLIABrain, 1968
- An electron microscopic study of the neuroglia during postnatal development of the rat cerebrumJournal of Comparative Neurology, 1968