Pre- or Post-Eruptive Effects of Strontium Alone or in Combination with Fluoride on Dental Caries in the Rat

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Abstract
Doses of strontium were given pre-eruptively to rats at 0.0, 2.5, 5.0 and 10.0 μg Sr/10 g body weight, with or without fluoride at 1.0 μg/l0 g body weight by esophageal intubation. In a second experiment strontium at concentrations of 0, 50, 100 and 150 mg Sr/l, with and without fluoride at 10 mg/l, were given via the drinking water post-eruptively. Caries scores were made for buccolingual, morsal, sulcal und proximal lesions in all rats. Slight reductions in buccolingual caries scores were seen in rats given 5.0 μg Sr/10 g body weight pre-eruptively. Rats given post-eruptive doses of strontium only showed marked reductions in buccolingual scores with 50 mg Sr/l, and 10 mg F/l. No effect was seen on morsal, sulcal or proximal caries scores for any of the treatment regimens. The greatest reductions in buccolingual caries scores were found when a combination of 50 mg Sr/l and 10 mg F/l was given post-eruptively.

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