Enzymes of Glycerol Metabolism in Developing Rat Liver and Kidney

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Abstract
Three enzymes of glycerol metabolism, glycerol kinase, a-glycero-P dehydrogenase, and a-glycero-P oxidase were measured in rat liver from several days before birth to maturity. Two of the enzymes were also measured in kidney cortex and medulla. In liver, glycerol kinase increased with age 70-fold, glycero-P dehydrogenase 9-fold and the glycero-P oxidase 4-fold. In kidney cortex, glycerol kinase increased 25- fold but followed a more prolonged time course than in liver; glycero-P dehydrogenase rose only 3-fold. In kidney medulla, glycerokinase fell during the first few days of life then returned to the newborn level ; glycero-P dehydrogenase fell 50% during maturation. High dietary fat increased glycerol kinase in young adult liver, but not in kidney. High fat also increased liver glycerol, dihydroxyacetone phosphate and fructose-1,6-diphosphate.

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