Survival Associated With Treatment vs Observation of Localized Prostate Cancer in Elderly Men
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Open Access
- 13 December 2006
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 296 (22) , 2683-2693
- https://doi.org/10.1001/jama.296.22.2683
Abstract
The widespread adoption of prostate-specific antigen (PSA) screening has led to an increasing proportion of men being diagnosed with early stage and low- or intermediate-grade prostate cancer. Cohort studies have demonstrated the indolent nature of low- and intermediate-grade disease,1-3 making management (observation, radiation therapy, and radical prostatectomy) of these men controversial. Population-based studies of treatment for localized prostate cancer estimate that only between 7% and 17%4 of men diagnosed with low-risk localized disease choose observation as their initial therapy.Keywords
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