Major histocompatibility complex class II alleles and the course and outcome of MS

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Abstract
To the Editor: We read with interest the article by Weinshenker et al.,1 in which the authors made the typing of HLA II (DR and DQ) in 119 patients representing 73.4% of the population with MS evaluated in a population-based survey in Olmsted County, MN. As controls they used 100 consecutive blood donors from the same area. A positive association was found between MS and DR15-DQ6 and DR13-DQ7 and a negative one with DR1-DQ5 alleles. No linkage was observed between any haplotype and disease severity measured by the index progression (Expanded Disability Status Scale score [EDSS/duration in years]). We conducted a long prospective survey (from October 1990 to July 1996) for ascertaining the prevalence rate of MS in the sanitary area of Calatayud, northern Spain. We found 34 patients with clinical MS: a prevalence …

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