Insulin Degradation in Serum of a Patient with Apparent Insulin Resistance*
- 1 February 1981
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 52 (2) , 177-180
- https://doi.org/10.1210/jcem-52-2-177
Abstract
A case is presented of a thin diabetic male who was resistant to large doses of sc and im insulin but responded to small doses of insulin given iv. His serum contained an enzyme that degraded [l25I]insulin in vitro. We postulate that his apparent insulin resistance was due to inactivation of insulin at the injection site. We propose that the sera of patients with insulin resistance be tested for [125I]insulin-degradingactivity as a possible means of identifying patients with this syndrome.Keywords
This publication has 3 references indexed in Scilit:
- Matched glucose responses to insulin administered subcutaneously and intravenouslyDiabetologia, 1980
- Alterations in Insulin Absorption and in Blood Glucose Control Associated with Varying Insulin Injection Sites in Diabetic PatientsAnnals of Internal Medicine, 1980
- Insulin resistance caused by massive degradation of subcutaneous insulinDiabetes, 1979