ENDOCRINE MANIPULATION OF THE DUNNING PROSTATIC ADENOCARCINOMA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 17  (6) , 529-533
Abstract
The Dunning animal model [Copenhagen and Copenhagen-Fischer hybrid rats] was used to evaluate endocrine management of prostatic adenocarcinoma. Hypophysectomy, alone or in combination and orchiectomy plus stilbestrol were the most effective means of suppressing tumor growth. Medical adrenalectomy by aminoglutethimide administration was as effective as surgical ablation. Accessary organ weights bore no direct relationship to the inhibition of tumor growth.