Selectivity of Bevantolol Hydrochloride towards .ALPHA.- and .BETA.-Adrenoceptor Subtypes in Rat Cerebral Cortex.
- 1 January 1992
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 58 (2) , 193-196
- https://doi.org/10.1254/jjp.58.193
Abstract
Selectivity of bevantolol hydrochloride (NC-1400) towards alpha- and beta-adrenoceptor subtypes of rat cerebral cortex was examined in binding experiments and compared with propranolol. Bevantolol biphasically displaced the 3H-dihydroalprenolol binding. The affinity of bevantolol to beta 1-adrenoceptor was equal to that of propranolol. Bevantolol displaced 3H-prazosin binding monophasically but not 3H-p-aminoclonidine binding. These results suggest that bevantolol is a beta 1-adrenoceptor antagonist with a relatively high affinity to alpha 1-adrenoceptor subtypes.Keywords
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